First In-Human Study for Pancreatic Cancer Pain

First Trial to Ever Evaluate Radiofrequency (RF) Ablation in a Transvascular Approach to Reduce Pain Associated with Pancreatic Cancer

Study Design


Number of Subjects Involved in the Study


Clinical Site


Evaluate Ablation of Relevant Somatic Nerves and Pain Mitigation


Pancreatic Cancer Pain Management is Part of a $2.2 Billion Market

The current market capitalization of pancreatic cancer treatment is $2.2 billion*. This first In-Human Proof of Concept Study for Pancreatic Cancer Pain is the first step in obtaining approval to treat Pancreatic Cancer Pain with a first-of-its-kind technology and technique using Autononix’s platform technology, a proprietary microchip and unique antenna sensing array that delivers precise treatments through a simple and safe transvascular procedure.

* Precedence Research pancreatic-cancer-market

*Carvajal G. Pancreatic Cancer Related Pain: Review of Pathophysiology and Intrathecal Drug Delivery Systems for Pain Management. Pain Physician. 2021 Aug;24(5):E583-E594. PMID: 34323445. Article:


Significant Unmet Need

Autonomix’s platform technology has the potential to significantly increase remaining quality of life for pancreatic cancer patients, and even potentially extend overall survival.* The technology and new technique is a better alternative to the “treat and pray” approach common today, where doctors treat areas at random and pray they hit the right nerves, which can cause collateral damage.

Speed to Market

A fast speed to market is expected due to the probability of a “de novo” regulatory pathway and conducting the initial Proof of Concept trial in Eastern Europe, which is known for its expedient clinical trials.

Cost of Development

The Autonomix platform relies on catheter systems and techniques that are familiar to interventional radiologists (our expected primary user) and should require a minimum of physician training for successful use.

Problem - Opportunity

Creativity & Innovation

Pancreatic tumors often cause severe pain that is very difficult to manage.

Lack of Treatment Options

Injections of ethanol are difficult to control and can destroy nerve tissue indiscriminately. Opioids have significant side effects and are often not effective in fully managing the pain.

Durable Pain Relief

We are seeking to create a minimally invasive procedure to deliver a durable and meaningful reduction in the pain of the patient.

Targeted Treatments

Our device is being developed to travel within the vascular system and detect the individual nerve bundles causing pain.

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